Manickam Lab of Biotherapeutics Delivery

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Publications


Check out My NCBI Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/1Ni_9PHgehhk6/bibliography/public/

PUBLISHED articles

  1. J. R. Jhaveri, P. Khare, P. P. Pinky, Y. S. Kamte, M. N. Chandwani, J. Milosevic, N. Abraham, M. Sun, D. B. Stolz, K. M. Dave, S-y. Zheng, L. O’Donnell, D. S. Manickam. “Low pinocytic brain endothelial cells primarily utilize membrane fusion to internalize extracellular vesicles”. European Journal of Pharmaceutics and Biopharmaceutics 204 (2024) 114500. 2024_Jhaveri-Khare-Paul_EJPB
  2. K. M. Dave, V. R. Venna, K. S. Rao, D. B. Stolz, B. Brady, V. A. Quaicoe, M. E. Maniskas, E. E. Hildebrand, D. Green, M. Chen, J. Milosevic, S-y. Zheng, S. S. Shiva, L. D. McCullough, D. S. Manickam. “Mitochondria-containing extracellular vesicles from mouse vs. human brain endothelial cells for ischemic stroke therapy”, Journal of Controlled Release. Volume 373, September 2024, Pages 803-822. 2024_JCR_Dave
  3. P. Khare, S. X. Edgecomb, C. M. Hamadani, J.F. Conway, E.E.L. Tanner and D. S. Manickam. “Ionic liquid-coated lipid nanoparticles increase
    siRNA uptake into CNS targets”. We made it to the outside front cover of the journal! and our paper was listed as a “Popular Advance” 2024_Khare_NSA_OFC
  4. K.M. Dave, D.B. Stolz and D. S. Manickam. “Delivery of mitochondria-containing extracellular vesicles to the BBB for ischemic stroke therapy.” 2023_Dave_EODDExpert Opinion on Drug Delivery, https://doi.org/10.1080/17425247.2023.2279115.
  5. P. Khare, S. X. Edgecomb, C. M. Hamadani, E.E.L. Tanner and D. S. Manickam. “Lipid nanoparticle-mediated drug delivery to the brain.” Emerging Voices in Drug Delivery special issue, Advanced Drug Delivery Reviews 2023 Vol. 197 Pages 114861. 2023_Khare_ADDR
  6. K.M. Dave, D. B. Stolz, V. R. Venna, V.A. Quaicoe, M. E. Maniskas, M. J. Reynolds, R. Babidhan, D. X. Dobbins, M. Farinelli, A. Sullivan, T. N. Bhatia, H. Yankello, R. Reddy, Y. Bae, R. K. Leak, S. S. Shiva, L. D. McCullough, D. S Manickam. “Mitochondria-containing extracellular vesicles (EV) reduce mouse brain infarct sizes and EV/HSP27 protect ischemic brain endothelial cultures”.  Journal of Controlled Release, 2023 Vol. 354 Pages 368-393. 2022_Dave et al._JCR
  7. P. Khare, J. F. Conway and D. S. Manickam. Lipidoid nanoparticles increase ATP uptake into hypoxic brain endothelial cells. European Journal of Pharmaceutics and Biopharmaceutics, Vol. 180, 2022, Pages 238-250. 2022_Khare_EJPB
  8. K.M. Dave, D. X. Dobbins, M. Farinelli, A. Sullivan, J. Milosevic, D. Stolz, J. Kim, S. Zheng, D. S Manickam. Engineering Extracellular Vesicles to Modulate their Innate Mitochondrial Load. 2022 Young Innovators Special Issue of the Cellular and Molecular Bioengineering journal, accepted on 8/9/2022. 2022 CMBE Young Innovator_Dave…Manickam
  9. D S. Manickam. “Delivery of mitochondria via extracellular vesicles – A new horizon in drug delivery.” Journal of Controlled Release, 2022 Vol. 343 Pages 400-407.2022_JCR Oration
  10. P. Khare, K. M. Dave, Y. S. Kamte, M. A. Manoharan, L. A. O’Donnell, D S Manickam. Development of lipidoid nanoparticles for siRNA delivery to neural cells. DOI: 10.1208/s12248-021-00653-2, AAPS Journal Rising Stars in Drug Carriers special issue. Khare_et_al-2021-The_AAPS_Journal see editorial: The AAPS Journal Theme Issue_Rising Stars in Drug Delivery and Novel Carriers
  11. A. D’Souza, A. Burch, K. M. Dave, A. Sreeram, M. J. Reynolds, D. X. Dobbins, Y. S. Kamte, W. Zhao, C. Sabatelle, Gina M. Joy, Vishal Soman, Uma R. Chandran, Sruti S. Shiva, N. Quillinan, P. S. Herson and D S. Manickam. Microvesicles transfer mitochondria and increase mitochondrial function in brain endothelial cells, Journal of Controlled Release, 2021. 2021_D’Souza_JCR https://www.sciencedirect.com/science/article/pii/S0168365921004442
  12. D’Souza, A., K.M. Dave, R.A. Stetler, and D.S. Manickam, Targeting the blood-brain barrier for the delivery of stroke therapies. Advanced Drug Delivery Reviews, 2021. 2021 ADDR review 2021_DSouza_ADDR
  13. Dave KM, Zhao W, Hoover C, D’Souza A, and S Manickam D, Extracellular Vesicles Derived from a Human Brain Endothelial Cell Line Increase Cellular ATP Levels. AAPS PharmSciTech, 2021. 22(1): p. 18. https://rdcu.be/cc1mcDave_et_al-2021-AAPS_PharmSciTech see editorial: Salem-Lu2021_Article_NationalInstituteForPharmaceut
  14. K.M. Dave, L. Han, M. A. Jackson, L. Kadlecik, C. L. Duvall, D. S. Manickam. “DNA Polyplexes of a Phosphorylcholine-based Zwitterionic Polymer for Gene Delivery” Pharmaceutical Research, 2020. https://link.springer.com/article/10.1007/s11095-020-02899-52020_Dave_PharmRes
  15. K.M. Dave, L. Ali and D.S. Manickam.  “Characterization of the SIM-A9 cell line as a model of activated microglia in the context of neuropathic pain” PLOS ONE. 2020. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.02315972020_Dave_PLOS ONE
  16. W. Zhao, L. Han, Y. Bae and D. S. Manickam. “Lucifer Yellow is a Robust Paracellular Permeability Marker in a Cell Model of the Human BBB.” Journal of Visualized Experiments. 2019. https://www.jove.com/video/58900/lucifer-yellow-robust-paracellular-permeability-marker-cell-model2019_Zhao_JOVE
  17. Jiang, J.M. Fay, C-D. Poon, N. Vinod, Y. Zhao, K. Bullock, S. Qin, D.S. Manickam, X. Yi, W.A. Banks, A.V. Kabanov. “Nanoformulation of Brain Derived Neurotrophic Factor with Target Receptor Triggered Release in Central Nervous System.” Advanced Functional Materials, 2018, 28 (6), 1703982. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958903/Jiang-2018-Nanoformulation-of-brain-derived-ne
  18. N. M. Harris, R. Ritzel, N. Mancini, Y. Jiang, X. Yi, D.S. Manickam, W.A. Banks, A.V. Kabanov, L.D. McCullough and R. Verma. “Nano-particle Delivery of Brain Derived Neurotrophic Factor after Focal Cerebral Ischemia reduces Tissue Injury and Enhances Behavioral Recovery.” Pharmacology, Biochemistry and Behavior, 2016, 2016, 150-151, 48-56. https://www.ncbi.nlm.nih.gov/pubmed/276196362016_Harris_PharmacolBiochemBehav
  19.  Y. Jiang, P. Arounleut, S. Rheiner, Y. Bae, A.V. Kabanov, C. Milligan and D. S. Manickam†. “SOD1 Nanozyme with Reduced Toxicity and MPS Accumulation.” Journal of Controlled Release, 2016, 231, 38-49 (†senior corresponding author). https://www.ncbi.nlm.nih.gov/pubmed/269285282016_Jiang_JCR
  20. V. Saraswathi, M. Ganesan; C. Perriotte-Olson, D.S. Manickam; R. A Westwood, M.C. Zimmerman, I. M Ahmad, C. V. Desouza, A. V Kabanov. “Nanoformulated Copper/Zinc Superoxide Dismutase Attenuates Vascular Cell Activation and Aortic Inflammation in Obesity.” Biochemical and Biophysical Research Communications, 2016, 469(3), 495–500. https://www.ncbi.nlm.nih.gov/pubmed/26692492
  21. C. Perriotte-Olson, N. Adi, D.S. Manickam, R. A. Westwood, C. V. Desouza, A. V. Kabanov, and S. Viswanathan. “Nanoformulated Copper/Zinc Superoxide Dismutase Reduces Adiposity and Adipose Inflammation in Obesity.” Obesity, 2016, 24(1), 148-56. http://onlinelibrary.wiley.com/doi/10.1002/oby.21348/pdf
  22. O. A. Kost, O.V. Beznos, N.G. Davydova, D.S. Manickam, I.I. Nikolskaya, A.E. Guller, P.V. Binevski, N.B. Chesnokova, A.B. Shekhter, N.L. Klyachko, A.V. Kabanov “Superoxide Dismutase 1 Nanozyme for Treatment of Eye Inflammation.” Oxidative Medicine and Cellular Longevity, 2016, vol. 2016, Article ID 5194239. https://www.ncbi.nlm.nih.gov/pubmed/26697135
  23. Y. Jiang, A.M. Brynskikh, D.S. Manickam† and A.V. Kabanov†. “SOD1 Nanozyme Salvages Ischemic Brain by Locally Protecting Cerebral Vasculature.” Journal of Controlled Release, 2015, 213, 36-44 (†senior co-corresponding author). https://www.ncbi.nlm.nih.gov/pubmed/26093094
  24. Z. He, L. Miao, R. Jordan, D.S. Manickam, R. Luxenhofer, A.V. Kabanov. “A Low Protein Binding Cationic Poly(2-oxazoline) as Non-Viral Vector.” Macromolecular Bioscience, 2015, 15, 1004-1020. https://www.ncbi.nlm.nih.gov/pubmed/25846127
  25. K. Savalia, D.S. Manickam, E.G. Rosenbaugh, J. Tian, I.M. Ahmad, A.V. Kabanov, M.C. Zimmerman. Neuronal Uptake of Nanoformulated Superoxide Dismutase and Inhibition of Angiotensin II-Dependent Hypertension Following Central Administration. Free Radical Biology and Medicine, 2014, 73, 299-307. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116739/
  26. N. L. Klyachko, M.H. Haney, Y. Zhao, D.S. Manickam, V. Mahajan, P. Suresh, R.L. Mosley, H.E. Gendelman, A.V. Kabanov, E.V. Batrakova. “Macrophages Offer a Paradigm Switch for CNS Nanozyme Delivery.” Nanomedicine, 2013, 1-18. https://www.ncbi.nlm.nih.gov/pubmed/24237263
  27. D. S. Manickam†, A.M. Brynskikh, J.L. Kopanic, P.L. Sorgen, N.L. Klyachko, E.V. Batrakova, T.K. Bronich and A.V. Kabanov†. “Well-defined Antioxidant Nanozymes for Treatment of Ischemic Brain Injury.” Journal of Controlled Release, 2012, 162(3), 636-45. (†co-corresponding author). https://www.ncbi.nlm.nih.gov/pubmed/22902590
  28.  J. Li, D.S. Manickam, J. Chen, D. Oupický. “Effect of Reduction-triggered Disassembly on Transfection Activity of Bioreducible Polyplexes.” European Journal of Pharmaceutical Sciences, 2012, 46(3), 173-80. https://www.ncbi.nlm.nih.gov/pubmed/22406090
  29.  N. L. Klyachko*, D.S. Manickam*, A.M. Brynskikh, S. Li, S.M. Higginbotham, T.K. Bronich, E.V. Batrakova, A.V. Kabanov. “Cross-Linked Antioxidant Nanozymes for Improved Delivery to CNS.” (*equal contribution), Nanomedicine: Nanotechnology, Biology and Medicine, 2012, 8(1), 119-29. https://www.ncbi.nlm.nih.gov/pubmed/21703990
  30. E. G. Rosenbaugh, J. Roat, L. Gao, R-F. Yang, D.S. Manickam, J-X. Yin, H.D. Schultz, T.K. Bronich, E.V. Batrakova, A.V. Kabanov, I.H. Zucker, M.C. Zimmerman. “Nanoformulated Copper/Zinc Superoxide Dismutase Attenuates Central Angiotensin II-dependent Pressor Response and Intra-neuronal Signaling.” Biomaterials, 2010, 31(19), 5218-5226. https://www.ncbi.nlm.nih.gov/pubmed/20378166
  31. D. S. Manickam, J. Li, D. A. Putt, Q.H. Zhou, C. Wu, L.H. Lash and D. Oupický. “Effect of Innate Glutathione Levels on Activity of Redox-responsive Gene Delivery Vectors.” Journal of Controlled Release, 2010, 141, 77-84. https://www.ncbi.nlm.nih.gov/pubmed/19720098
  32. Q-H. Zhou, C. Wu, D.S. Manickam and D. Oupický. “Evaluation of Pharmacokinetics of Bioreducible Gene Delivery Vectors by Real-time PCR.” Pharmaceutical Research, 2009, 26(7), 1581-1589. https://www.ncbi.nlm.nih.gov/pubmed/19240986
  33. S. Kakade, D.S. Manickam, H. Handa, G. Mao, and D. Oupický. “Transfection Activity of Layer-by-Layer Plasmid DNA/Poly(ethylenimine) Films Deposited on PLGA Microparticles.” International Journal of Pharmaceutics, 2009, 365(1-2), 44-52. https://www.ncbi.nlm.nih.gov/pubmed/18786622
  34. L. Wan, D.S. Manickam, D. Oupický, and G. Mao. “DNA Release Dynamics from Reducible Polyplexes by Atomic Force Microscopy.” Langmuir, 2008, 24(21), 12474-12482. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825055/
  35. D.S. Manickam, A. Hirata, D.A. Putt, L.H. Lash, F. Hirata and D. Oupický. “Overexpression of Bcl-2 as a Proxy Redox Stimulus to Enhance Activity of Reducible Gene Delivery Vectors.” Biomaterials, 2008, 29, 2680–2688. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2393550/
  36. U. L. Rahbek, K.A. Howard, D. Oupický, D.S. Manickam, M. Dong, A.F. Nielsen, F. Besenbacher and J. Kjems. “Intracellular siRNA and Precursor miRNA Trafficking Using Bioresponsive Copolypeptides.” Journal of Gene Medicine, 2008, 10(1), 81-93. http://europepmc.org/abstract/med/18000993
  37. Y-Z. You, Q.H. Zhou, D.S. Manickam, L. Wan, G.Z. Mao, and D. Oupický. “Dually Responsive Multiblock Copolymers via RAFT Polymerization: Synthesis of Temperature- and Redox-responsive Copolymers of PNIPAM and PDMAEMA.” Macromolecules, 2007, 40(24), 8617-8624. http://pubs.acs.org/doi/abs/10.1021/ma071176p
  38. Y-Z. You, S. Manickam, Q.H. Zhou and D. Oupický. “A Versatile Approach to Reducible Vinyl Polymers via Oxidation of Telechelic Polymers Prepared by Reversible Addition Fragmentation Chain Transfer Polymerization.” Biomacromolecules, 2007, 8, 2038-2044. http://pubs.acs.org/doi/abs/10.1021/bm0702049
  39. Y-Z. You*, S. Manickam*, Q.H. Zhou and D. Oupický. “Reducible Poly(2-dimethylaminoethylmethacrylate): Synthesis, Cytotoxicity, and Gene Delivery Activity.” Journal of Controlled Release, 2007, 122, 217-225. (*equal contribution) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063492/
  40. J. Blacklock, H. Handa, D.S. Manickam, G. Mao, A. Mukhopadhyay and D. Oupický. “Disassembly of Layer-by-Layer Films of Plasmid DNA and Reducible TAT Polypeptide.” Biomaterials, 2007, 28, 117-124. http://www.sciencedirect.com/science/article/pii/S0142961206007502
  41. D. S. Manickam and D. Oupický. “Multiblock Reducible Copolypeptides Containing Histidine-rich and Nuclear Localization Sequences for Gene Delivery.” Bioconjugate Chemistry, 2006, 17, 1395-1403. https://www.ncbi.nlm.nih.gov/pubmed/17105216
  42. H. S. Bisht*, D.S. Manickam*, Y. You, and D. Oupický. “Temperature-Controlled Properties of DNA Complexes with Poly (ethylenimine)-graft-poly (N-isopropylacrylamide).” Biomacromolecules, 2006, 7, 1169-1178. (*equal contribution). https://www.ncbi.nlm.nih.gov/pubmed/16602735
  43. D. S. Manickam, H.S. Bisht, L. Wan, G. Mao and D. Oupický. “Influence of TAT-peptide Polymerization on Properties and Transfection Activity of TAT/DNA Polyplexes.” Journal of Controlled Release, 2005, 102(1), 293-306. https://www.ncbi.nlm.nih.gov/pubmed/15653153
Reviews
  1. X. Yi, D.S. Manickam, A.M. Brynskikh and A.V. Kabanov. Agile Delivery of Protein Therapeutics to CNS. Journal of Controlled Release, 2014. 190, 637-663. https://www.ncbi.nlm.nih.gov/pubmed/24956489

2. E. G. Rosenbaugh, K.K. Savalia, D.S. Manickam, and M.C. Zimmerman. “Antioxidant-based therapies for angiotensin II-associated cardiovascular diseases.” American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, 2013. 304(11), R917-R928 (listed in ‘Editor’s Picks’ in the July 2013 issue). https://www.ncbi.nlm.nih.gov/pubmed/23552499

3. D. S. Manickam and D. Oupický. “Polyplex Gene Delivery Modulated by Redox Potential Gradients.” Journal of Drug Targeting, 2006, 14(8), 519-26. https://www.ncbi.nlm.nih.gov/pubmed/17050118

4. D. Oupický, H.S. Bisht, D.S. Manickam and Q. Zhou. “Stimulus-controlled Delivery of Drugs and Genes.” Expert Opinion on Drug Delivery, 2005, 2(4), 653-665. https://www.ncbi.nlm.nih.gov/pubmed/16296792

 Book chapters
  1. Y. Zhu, J. Li, Y. Wang, D.S. Manickam, Y. You, D. Oupický. “Redox-responsive polymer-based gene delivery systems.” In Gene and Cell Therapy: Therapeutic Mechanisms and Strategies. 4th Edition, Ed. N. S. Templeton, Taylor and Francis, Boca Raton, 2014.

2. D. Oupický, Y. You and D.S. Manickam. “Redox-responsive Polymer-based Gene Delivery Systems.” In Gene and Cell Therapy: Therapeutic Mechanisms and Strategies. 3rd Edition, Ed. N. S. Templeton, Taylor and Francis, Boca Raton, 2007.

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